Team Leader
Hannah Smith
Texas A&M University
Neuroscience and Experimental Therapeutics
hannahsmith@tamu.edu
Project Type
Research
Who Can Join
Undergraduate Students
Project Description
Military personnel frequently experience chronic sleep disruption due to shift work, irregular schedules, nighttime light exposure, and travel across time zones. These disruptions impair circadian rhythms and are associated with increased risks for cognitive decline, immune dysfunction, mood disorders, and Alzheimer’s disease and related dementias (AD/ADRD).
This project investigates how circadian rhythm disruption contributes to age-related cognitive decline and immune dysregulation using translational rodent models. By combining behavioral assessments of sleep-wake patterns, immune profiling, and spatial learning and memory testing, the study aims to identify early behavioral and biological markers that precede measurable cognitive impairment. Cognitive performance will be evaluated using the Barnes maze and a Cognitive Index (CI) designed to characterize age-related changes in learning and memory.
The findings may improve understanding of how chronic sleep and circadian disturbances accelerate neurodegeneration and immune dysfunction, supporting the development of early detection strategies and interventions for at-risk populations, including military personnel, shift workers, and aging adults.
Team Needs
Interest in neuroscience, aging, sleep/circadian biology, or neurodegenerative disease research
Detail-oriented with strong organizational skills
Reliable and able to complete tasks in a timely manner
Clear and professional communication skills
Experience with or willingness to learn animal handling and behavioral testing techniques
Ability to work independently and collaboratively in a team environment
Strong data collection and record-keeping skills
Basic laboratory skills and adherence to research protocols
Willingness to learn new experimental and analytical techniques
Commitment to ethical research practices and animal care standards
Special Opportunities
Depending on performance, commitment, and level of involvement, team members may have opportunities to:
Present research findings at laboratory meetings, university research events, or scientific conferences
Contribute to abstracts, posters, or publications
Gain hands-on experience with behavioral neuroscience and circadian biology research techniques
Develop skills in data analysis, experimental design, and scientific communication
Receive mentorship for graduate school or research career development