Team Leader
Hoda Ahmed
Texas A&M School of Medicine
Cell Biology and Genetics
hahmed2@tamu.edu
Project Type
Research
Who Can Join
Undergraduate Students
Project Description
Closed head injury (CHI), the most common form of traumatic brain injury (TBI), can lead to long-term problems with learning, memory, and mood. Repeated CHI (rCHI), which can occur in military settings or contact-related injuries, increases the risk of chronic brain inflammation and neurodegenerative conditions.
Our research aims to develop a noninvasive intranasal therapy using extracellular vesicles (EVs), which are small particles released by cells that carry biologically active molecules such as microRNAs. These EVs are derived from human induced pluripotent stem cell–derived neural stem cells (hiPSC-NSCs) and may help reduce inflammation and protect brain function after injury. Using a mouse model of rCHI, we investigate how this therapy can protect or restore cognitive and mood function.
Team Needs
We are looking for motivated undergraduate students interested in neuroscience, biomedical sciences, or translational/medical research.
Previous laboratory experience is not required; however, familiarity with basic cellular and/or molecular biology laboratory skills is preferred, including pipetting techniques, media preparation, microscopy, and DNA/RNA extraction.
Students interested to learn the following research approaches are encouraged to apply:
– Analysis of gene expression in brain tissues using RT-qPCR
– Single, dual immunofluorescence, and Confocal Microscopy
– Western Blotting
– Mouse handling and conducting neurobehavioral tests assessing cognitive and mood function
Special Opportunities
– Hands-on experience with cutting-edge research in mouse models of brain injury, cognitive and mood function testing in mouse models
– Mentorship in scientific literature analysis and scientific presentations
– Guidance and mentoring to support career development in science and research
– Opportunities to present research findings in poster or oral formats at local research symposiums
– Exposure to additional research projects in the laboratory, including studies investigating therapies to enhance brain function in Gulf War Illness and Alzheimer’s disease
Students interested in joining the team are encouraged to contact Dr. Hoda Ahmed via email with a brief statement of interest and CV/resume.